This has been a tough week in the world, so I thought you might like a little diversion.
Sometimes I hear interesting words or phrases that pique my curiosity. These three phrases suggested meanings, but when I checked, I discovered the real meanings were very different.
Compliment activation – What I hope will happen after I get my hair cut or if I’m showing off a new pair of shoes.
When I first heard this term at a medical conference in a previous life, I was delighted. After all, I’m a writer and love expressive language. But if you spell this the scientific way —“complement activation,” you get the real meaning:
The complement system includes 20+ protein molecules that circulate in the blood. When the body senses a pathogen (the cooties that cause disease), the complement system is activated and a sequence of events occurs to fight infection. So either kind of complement activation can be good for you.
Antisense – Sounds like a good description for current events. Also might describe what the chipmunks in my yard are saying.
“Antisense” just covers so many situations. Turns out, it also has a scientific meaning: Having a sequence of nucleotides complementary to (and hence capable of binding to) a coding sequence, which may be either that of the strand of a DNA double helix that undergoes transcription, or that of a messenger RNA molecule (Dictionary.com).
After more research, I learned that the concept of antisense evolved into a therapy for genetic disorders. When a particular gene is responsible for a disease, a strand of nucleic acid can be bound to the messenger RNA of that gene and effectively switch off the disease-causing gene.
Regional expression – OK, I think I got this. A regional expression is like “pop” in the Midwest or “soda” on the East coast. Or maybe the way I say, “crick” for “creek” – an Ohio thing. Unless we’re talking about genetics.
Every gene contains a particular set of instructions that code for a specific protein. Gene expression is the process that enables DNA instructions to be converted into something useful, such as a protein. Where a gene lies in the genome (its region or neighborhood) influences the regulation of gene expression. In other words, gene behavior is influenced by where it hangs out. Hmm. Just like people.
It can’t hurt to know a bit more about genetics, but I like my definitions better!